Immune Escape Human Gliomas: An Alternative Strategy of A Functional Role of HLA-G Expression in
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Analysis of HLA-G Gene Expression in B-Lymphocytes from Chronic Lymphocytic Leukemia Patients
The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...
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Background and Aims: Human leukocyte antigen (HLA) molecules play a substantial role in T Lymphocyte-mediated adaptive immune response. Down-regulation of HLA expression may help the tumor to escape from immune surveillance. This study aimed to evaluate the correlation between HLA-G and HLA-E tissue distribution and the degree of tumor malignancy in human breast tumors. Materials and Methods:...
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Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...
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HLA-G is a nonclassical HLA class Ib, which is located on chromosome 6 (6p.21.3). In contrast to HLA class I molecules, HLA-G has restricted polymorphism. Expression of this molecule in the physiological conditions limits to certain tissues such as thymus, cornea, nail matrix, trophoblast and pancreas. Up to now, 50 alleles of HLA-G molecules have been discovered with 16 distinct functional pro...
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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
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